Reactome | AFG3L2:SPG7 binds SMDT1 (EMRE)

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AFG3L2:SPG7 binds SMDT1 (EMRE) Show undefined attributes

category	binding
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10324493
displayName	AFG3L2:SPG7 binds SMDT1 (EMRE)
eventOf	[Pathway:R-CFA-9837999] Mitochondrial protein degradation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-9839059] AFG3L2:SPG7 degrades SMDT1 (EMRE) - Canis familiaris
inferredFrom	[Reaction:R-HSA-9839053] AFG3L2:SPG7 binds SMDT1 (EMRE) - Homo sapiens
input	[Complex:R-CFA-9838612] AFG3L2:Zn2+:SPG7:Zn2+ heterohexamer [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-CFA-8949227] SMDT1 [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	AFG3L2:SPG7 binds SMDT1 (EMRE)
output	[Complex:R-CFA-9839141] AFG3L2:SPG7:SMDT1 [mitochondrial inner membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9839053
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9837999] Mitochondrial protein degradation
(precedingEvent)	[BlackBoxEvent:R-CFA-9839059] AFG3L2:SPG7 degrades SMDT1 (EMRE)
(inferredTo)	[Reaction:R-HSA-9839053] AFG3L2:SPG7 binds SMDT1 (EMRE)

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