Reactome | CUL3:RBX1 ubiquitinates KEAP1

Schema > Reaction > Entries

CUL3:RBX1 ubiquitinates KEAP1 Show undefined attributes

catalystActivity	[CatalystActivity:10322674] ubiquitin protein ligase activity of SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10322676
displayName	CUL3:RBX1 ubiquitinates KEAP1
eventOf	[Pathway:R-CFA-9755511] KEAP1-NFE2L2 pathway - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9766645] CUL3:RBX1 ubiquitinates KEAP1 - Homo sapiens
input	[Complex:R-CFA-9766685] SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] 3 × [DefinedSet:R-CFA-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CUL3:RBX1 ubiquitinates KEAP1
output	[Complex:R-CFA-9766649] SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol]
precedingEvent	[Reaction:R-CFA-9766687] SESN1,SESN1 bind SQSTM1 and KEAP1 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9766645
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9755511] KEAP1-NFE2L2 pathway
(inferredTo)	[Reaction:R-HSA-9766645] CUL3:RBX1 ubiquitinates KEAP1

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