Reactome | Dimethyl fumarate modifies Cys191 in GSDMD

Schema > Reaction > Entries

category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10321647
displayName	Dimethyl fumarate modifies Cys191 in GSDMD
eventOf	[Pathway:R-CFA-5620971] Pyroptosis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9716258] Dimethyl fumarate modifies Cys191 in GSDMD - Homo sapiens
input	[CandidateSet:R-ALL-9716226] fumarate analogs [cytosol] [EntityWithAccessionedSequence:R-CFA-6801577] GSDMD [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Dimethyl fumarate modifies Cys191 in GSDMD
output	[EntityWithAccessionedSequence:R-CFA-9716198] GSDMD [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9716258
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-5620971] Pyroptosis
(inferredTo)	[Reaction:R-HSA-9716258] Dimethyl fumarate modifies Cys191 in GSDMD

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