Reactome | Hemes bind LY96

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10320984
displayName	Hemes bind LY96
eventOf	[Pathway:R-CFA-9707616] Heme signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9707659] Hemes:LY96 activates TLR4 - Canis familiaris
inferredFrom	[Reaction:R-HSA-9707594] Hemes bind LY96 - Homo sapiens
input	[CandidateSet:R-ALL-9707310] Hemes [extracellular region] [EntityWithAccessionedSequence:R-CFA-9707658] LY96 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Hemes bind LY96 Heme binds to MD-2
output	[Complex:R-CFA-9707530] Hemes:LY96 [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9707594
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-9707616] Heme signaling
(precedingEvent)	[Reaction:R-CFA-9707659] Hemes:LY96 activates TLR4
(inferredTo)	[Reaction:R-HSA-9707594] Hemes bind LY96

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