Reactome | p-Y705,S727 STAT3 is acetylated

Schema > Reaction > Entries

p-Y705,S727 STAT3 is acetylated Show undefined attributes

catalystActivity	[CatalystActivity:10320712] protein-lysine-acetyltransferase activity of EP300 [nucleoplasm]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10320714
displayName	p-Y705,S727 STAT3 is acetylated
eventOf	[Pathway:R-CFA-9701898] STAT3 nuclear events downstream of ALK signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9701565] HDACs deacetylate p-STAT3 dimers - Canis familiaris
inferredFrom	[Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated - Homo sapiens
input	[SimpleEntity:R-ALL-113560] Ac-CoA [nucleoplasm] [Complex:R-CFA-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	p-Y705,S727 STAT3 is acetylated
output	[Complex:R-CFA-9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] [SimpleEntity:R-ALL-2485002] CoA-SH [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-CFA-9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9701531
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9701898] STAT3 nuclear events downstream of ALK signaling
(precedingEvent)	[Reaction:R-CFA-9701565] HDACs deacetylate p-STAT3 dimers
(inferredTo)	[Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated

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