Reactome | PP6-PPP6R3 dephosphorylates TERF2

Schema > Reaction > Entries

PP6-PPP6R3 dephosphorylates TERF2 Show undefined attributes

catalystActivity	[CatalystActivity:10320256] protein serine/threonine phosphatase activity of PP6-PPP6R3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10320258
displayName	PP6-PPP6R3 dephosphorylates TERF2
eventOf	[Pathway:R-CFA-171319] Telomere Extension By Telomerase - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-163096] Recruitment of Telomerase RNP to the Telomeric Chromosome End - Canis familiaris [Reaction:R-CFA-9686521] CDK2:CCNA phosphorylates TERF2 - Canis familiaris
inferredFrom	[Reaction:R-HSA-9686524] PP6-PPP6R3 dephosphorylates TERF2 - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-CFA-9686523] Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PP6-PPP6R3 dephosphorylates TERF2
output	[SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-CFA-9671076] Telomeric G-strand chromosome end:Shelterin [nucleoplasm]
precedingEvent	[Reaction:R-CFA-9686521] CDK2:CCNA phosphorylates TERF2 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9686524
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-171319] Telomere Extension By Telomerase
(precedingEvent)	[Reaction:R-CFA-163096] Recruitment of Telomerase RNP to the Telomeric Chromosome End [Reaction:R-CFA-9686521] CDK2:CCNA phosphorylates TERF2
(inferredTo)	[Reaction:R-HSA-9686524] PP6-PPP6R3 dephosphorylates TERF2