Reactome | GSDME (1-270) binds PIPs

Schema > Reaction > Entries

GSDME (1-270) binds PIPs Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10319462
displayName	GSDME (1-270) binds PIPs
eventOf	[Pathway:R-CFA-5620971] Pyroptosis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9710254] GSDME oligomerizes - Canis familiaris
inferredFrom	[Reaction:R-HSA-9647660] GSDME (1-270) binds PIPs - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-9647689] GSDME [cytosol] [DefinedSet:R-ALL-5620974] PI4P,PI(4,5)P2,PIP3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	GSDME (1-270) binds PIPs
output	[Complex:R-CFA-9647679] GSDME (1-270):PIPs [plasma membrane]
precedingEvent	[BlackBoxEvent:R-CFA-9647632] CASP3 cleaves GSDME - Canis familiaris [BlackBoxEvent:R-CFA-9710263] GZMB cleaves GSDME - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9647660
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5620971] Pyroptosis
(precedingEvent)	[Reaction:R-CFA-9710254] GSDME oligomerizes
(inferredTo)	[Reaction:R-HSA-9647660] GSDME (1-270) binds PIPs

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