Reactome | NEIL1 cleaves thymine glycol from damaged DNA

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NEIL1 cleaves thymine glycol from damaged DNA Show undefined attributes

catalystActivity	[CatalystActivity:10318768] DNA N-glycosylase activity of NEIL1:Tg-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10318770
displayName	NEIL1 cleaves thymine glycol from damaged DNA
eventOf	[Pathway:R-CFA-110329] Cleavage of the damaged pyrimidine - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9629149] NEIL1 cleaves thymine glycol from damaged DNA - Homo sapiens
input	[Complex:R-CFA-9629155] NEIL1:Tg-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NEIL1 cleaves thymine glycol from damaged DNA
output	[Complex:R-CFA-5649669] NEIL1:AP-dsDNA [nucleoplasm] [SimpleEntity:R-ALL-110223] Tg [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9629149
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-110329] Cleavage of the damaged pyrimidine
(inferredTo)	[Reaction:R-HSA-9629149] NEIL1 cleaves thymine glycol from damaged DNA

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