Reactome | p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A

Schema > BlackBoxEvent > Entries

p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10262270
displayName	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
eventOf	[Pathway:R-CFA-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-927836] SMG6 hydrolyzes mRNA with premature termination codon - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-430043] DCP1A [cytosol] [EntityWithAccessionedSequence:R-CFA-8879146] PNRC2 [cytosol] [Complex:R-CFA-377182] PP2A (Aalpha:B55alpha:Calpha) [cytosol] [Complex:R-CFA-927890] SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] [EntityWithAccessionedSequence:R-CFA-927867] SMG5 [cytosol] [EntityWithAccessionedSequence:R-CFA-927851] SMG6 [cytosol] [EntityWithAccessionedSequence:R-CFA-927838] SMG7 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
output	[Complex:R-CFA-927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
precedingEvent	[Reaction:R-CFA-927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-927813
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
(precedingEvent)	[BlackBoxEvent:R-CFA-927836] SMG6 hydrolyzes mRNA with premature termination codon
(inferredTo)	[BlackBoxEvent:R-HSA-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A