Reactome | ALOX5 oxidises EPA to 5-HEPE

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ALOX5 oxidises EPA to 5-HEPE Show undefined attributes

catalystActivity	[CatalystActivity:10317302] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10317717
displayName	ALOX5 oxidises EPA to 5-HEPE
eventOf	[Pathway:R-CFA-9027604] Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9027628] ALOX5 oxidises EPA to 5-HEPE - Homo sapiens
input	[SimpleEntity:R-ALL-2026977] EPA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX5 oxidises EPA to 5-HEPE
output	[SimpleEntity:R-ALL-9028283] 5-HEPE [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9027628
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9027604] Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives
(inferredTo)	[Reaction:R-HSA-9027628] ALOX5 oxidises EPA to 5-HEPE

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