Reactome | The p75NTR:NgR:MDGI binds RHOA-GDI

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The p75NTR:NgR:MDGI binds RHOA-GDI Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10316526
displayName	The p75NTR:NgR:MDGI binds RHOA-GDI
eventOf	[Pathway:R-CFA-193634] Axonal growth inhibition (RHOA activation) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Canis familiaris
inferredFrom	[Reaction:R-HSA-9012761] The p75NTR:NgR:MDGI binds RHOA-GDI - Homo sapiens
input	[Complex:R-CFA-194499] NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] [Complex:R-CFA-194533] RHOA:GDP:ARHGDIA [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	The p75NTR:NgR:MDGI binds RHOA-GDI
output	[Complex:R-CFA-194481] RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9012761
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-193634] Axonal growth inhibition (RHOA activation)
(precedingEvent)	[Reaction:R-CFA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
(inferredTo)	[Reaction:R-HSA-9012761] The p75NTR:NgR:MDGI binds RHOA-GDI

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