Reactome | EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K

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EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10316515
displayName	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
eventOf	[Pathway:R-CFA-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris
inferredFrom	[Reaction:R-HSA-9012657] EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K - Homo sapiens
input	[Complex:R-CFA-9027242] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] [DefinedSet:R-CFA-9012640] PI3K alpha, gamma [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
output	[Complex:R-CFA-9012639] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane]
precedingEvent	[Reaction:R-CFA-9027272] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9012657
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
(precedingEvent)	[Reaction:R-CFA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3
(inferredTo)	[Reaction:R-HSA-9012657] EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K

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