Reactome | SLIT2:ROBO1 increases RHOA activity

Schema > Pathway > Entries

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331631
displayName	SLIT2:ROBO1 increases RHOA activity
eventOf	[Pathway:R-CFA-376176] Signaling by ROBO receptors - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-8985594] MYO9B inactivates RHOA - Canis familiaris
inferredFrom	[Pathway:R-HSA-8985586] SLIT2:ROBO1 increases RHOA activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SLIT2:ROBO1 increases RHOA activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-8985586
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-376176] Signaling by ROBO receptors
(inferredTo)	[Pathway:R-HSA-8985586] SLIT2:ROBO1 increases RHOA activity

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