Reactome | JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3

Schema > BlackBoxEvent > Entries

JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10315614
displayName	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
eventOf	[Pathway:R-CFA-8984722] Interleukin-35 Signalling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-8984023] p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-8984014] JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-8983998] IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-8984010] IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-CFA-8984021] STAT1,STAT3 associate with IL27RA:IL12RB2 receptor - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-8984014
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8984722] Interleukin-35 Signalling
(precedingEvent)	[BlackBoxEvent:R-CFA-8984023] p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
(inferredTo)	[BlackBoxEvent:R-HSA-8984014] JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3

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