Reactome | MET activates RAP1 and RAC1

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MET activates RAP1 and RAC1 Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331551
displayName	MET activates RAP1 and RAC1
eventOf	[Pathway:R-CFA-8875878] MET promotes cell motility - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-8875540] GAB1 recruits CRK,CRKL to MET - Canis familiaris [Reaction:R-CFA-8875558] RAPGEF1 binds CRK,CRKL - Canis familiaris [Reaction:R-CFA-8875568] RAPGEF1 activates RAP1 - Canis familiaris [BlackBoxEvent:R-CFA-8875576] CRK,CRKL recruits RAC1 GEF to activated MET - Canis familiaris [BlackBoxEvent:R-CFA-8875591] DOCK7 activates RAC1 - Canis familiaris
inferredFrom	[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	MET activates RAP1 and RAC1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-8875555
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8875878] MET promotes cell motility
(inferredTo)	[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1

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