Reactome | USP8 deubiquitinates LRIG1

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USP8 deubiquitinates LRIG1 Show undefined attributes

catalystActivity	[CatalystActivity:10310641] cysteine-type deubiquitinase activity of USP8 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10310643
displayName	USP8 deubiquitinates LRIG1
eventOf	[Pathway:R-CFA-6807004] Negative regulation of MET activity - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8875443] USP8 deubiquitinates LRIG1 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-CFA-8875433] MET:Ub-LRIG1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	USP8 deubiquitinates LRIG1
output	[Complex:R-CFA-8875375] MET:LRIG1 [plasma membrane] [DefinedSet:R-CFA-113595] Ub [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8875443
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6807004] Negative regulation of MET activity
(inferredTo)	[Reaction:R-HSA-8875443] USP8 deubiquitinates LRIG1

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