Reactome | Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle

Schema > Reaction > Entries

Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle Show undefined attributes

category	binding
compartment	[Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10309721
displayName	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
eventOf	[Pathway:R-CFA-8856828] Clathrin-mediated endocytosis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Canis familiaris
inferredFrom	[Reaction:R-HSA-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle - Homo sapiens
input	[Complex:R-CFA-5251937] HSPA8:ATP [cytosol] [Complex:R-CFA-8868626] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
output	[Complex:R-CFA-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-CFA-8868659] Clathrin recruits auxilins to the clathrin-coated vesicle - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8868660
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-CFA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
(inferredTo)	[Reaction:R-HSA-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle