Reactome | PTPN22 dissociates from CSK

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PTPN22 dissociates from CSK Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10307996
displayName	PTPN22 dissociates from CSK
eventOf	[Pathway:R-CFA-202427] Phosphorylation of CD3 and TCR zeta chains - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-8855381] PTPN22 dephosphorylates ZAP70 - Canis familiaris [Reaction:R-CFA-8852200] Inactivation of LCK by PTPN22 - Canis familiaris
inferredFrom	[Reaction:R-HSA-8855375] PTPN22 dissociates from CSK - Homo sapiens
input	[Complex:R-CFA-8855376] PTPN22:CSK [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTPN22 dissociates from CSK
output	[EntityWithAccessionedSequence:R-CFA-203776] CSK [cytosol] [EntityWithAccessionedSequence:R-CFA-8852205] PTPN22 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8855375
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CFA-8855381] PTPN22 dephosphorylates ZAP70 [Reaction:R-CFA-8852200] Inactivation of LCK by PTPN22
(hasEvent)	[Pathway:R-CFA-202427] Phosphorylation of CD3 and TCR zeta chains
(inferredTo)	[Reaction:R-HSA-8855375] PTPN22 dissociates from CSK

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