Reactome | IRS activation

Schema > Pathway > Entries

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328821
displayName	IRS activation
eventOf	[Pathway:R-CFA-74751] Insulin receptor signalling cascade - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-74707] Binding of IRS to insulin receptor - Canis familiaris [Reaction:R-CFA-74711] Phosphorylation of IRS - Canis familiaris [Reaction:R-CFA-74712] Dissociation of IRS-P from insulin receptor - Canis familiaris
inferredFrom	[Pathway:R-HSA-74713] IRS activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	IRS activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-74713
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-74751] Insulin receptor signalling cascade
(inferredTo)	[Pathway:R-HSA-74713] IRS activation