Reactome | FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

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FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi Show undefined attributes

catalystActivity	[CatalystActivity:10230519] phosphoribosylformylglycinamidine synthase activity of PFAS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10230521
displayName	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi
eventOf	[Pathway:R-CFA-73817] Purine ribonucleoside monophosphate biosynthesis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-73810] FGAM + ATP => AIR + ADP + Pi - Canis familiaris
inferredFrom	[Reaction:R-HSA-73812] FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol] [SimpleEntity:R-ALL-111354] N-Formyl-GAR [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+) 5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-111369] FGAM [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-CFA-73813] GAR + 10-Formyl-THF => FGAR + THF - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-73812
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-73817] Purine ribonucleoside monophosphate biosynthesis
(precedingEvent)	[Reaction:R-CFA-73810] FGAM + ATP => AIR + ADP + Pi
(inferredTo)	[Reaction:R-HSA-73812] FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

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