Reactome | CDK-mediated phosphorylation and removal of Cdc6

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CDK-mediated phosphorylation and removal of Cdc6 Show undefined attributes

compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328535
displayName	CDK-mediated phosphorylation and removal of Cdc6
eventOf	[Pathway:R-CFA-69052] Switching of origins to a post-replicative state - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-69005] Cdc6 protein is phosphorylated by CDK - Canis familiaris [Reaction:R-CFA-69006] Phosphorylated Cdc6 is exported from the nucleus - Canis familiaris [Reaction:R-CFA-69015] Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex - Canis familiaris [BlackBoxEvent:R-CFA-69016] Ubiquitinated Cdc6 is degraded by the proteasome - Canis familiaris
inferredFrom	[Pathway:R-HSA-69017] CDK-mediated phosphorylation and removal of Cdc6 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	CDK-mediated phosphorylation and removal of Cdc6
precedingEvent	[Pathway:R-CFA-68952] DNA replication initiation - Canis familiaris
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-69017
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(inferredTo)	[Pathway:R-HSA-69017] CDK-mediated phosphorylation and removal of Cdc6
(hasEvent)	[Pathway:R-CFA-69052] Switching of origins to a post-replicative state

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