Reactome | DNA Replication Pre-Initiation

Schema > Pathway > Entries

compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328509
displayName	DNA Replication Pre-Initiation
eventOf	[TopLevelPathway:R-CFA-69306] DNA Replication - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-CFA-68867] Assembly of the pre-replicative complex - Canis familiaris [Pathway:R-CFA-68962] Activation of the pre-replicative complex - Canis familiaris
inferredFrom	[Pathway:R-HSA-69002] DNA Replication Pre-Initiation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	DNA Replication Pre-Initiation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-69002
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[TopLevelPathway:R-CFA-69306] DNA Replication
(hasEncapsulatedEvent)	[Pathway:R-CFA-68962] Activation of the pre-replicative complex
(inferredTo)	[Pathway:R-HSA-69002] DNA Replication Pre-Initiation

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