Reactome | ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

Schema > Reaction > Entries

ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG Show undefined attributes

catalystActivity	[CatalystActivity:10304642] aldehyde dehydrogenase (NAD+) activity of ALDH1L1 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10304644
displayName	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG
eventOf	[Pathway:R-CFA-196757] Metabolism of folate and pterines - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG - Canis familiaris
inferredFrom	[Reaction:R-HSA-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG - Homo sapiens
input	[SimpleEntity:R-ALL-111353] 10-formyl-THFPG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-197969] THFPG [cytosol]
precedingEvent	[Reaction:R-CFA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Canis familiaris [Reaction:R-CFA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6808496
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-CFA-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG
(inferredTo)	[Reaction:R-HSA-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG