Reactome | HPN heterodimer cleaves pro-MST1 to form MST1 dimer

Schema > Reaction > Entries

HPN heterodimer cleaves pro-MST1 to form MST1 dimer Show undefined attributes

catalystActivity	[CatalystActivity:10302905] serine-type endopeptidase activity of HPN heterodimer [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10302917
displayName	HPN heterodimer cleaves pro-MST1 to form MST1 dimer
eventOf	[Pathway:R-CFA-8852405] Signaling by MST1 - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-6800315] MST1 binds MST1R - Canis familiaris
inferredFrom	[Reaction:R-HSA-6800198] HPN heterodimer cleaves pro-MST1 to form MST1 dimer - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [EntityWithAccessionedSequence:R-CFA-6800227] MST1 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	HPN heterodimer cleaves pro-MST1 to form MST1 dimer
output	[Complex:R-CFA-6800213] MST1 dimer [extracellular region]
regulatedBy	[NegativeRegulation:10302918] Negative regulation by 'SPINT1,2 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6800198
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8852405] Signaling by MST1
(precedingEvent)	[Reaction:R-CFA-6800315] MST1 binds MST1R
(inferredTo)	[Reaction:R-HSA-6800198] HPN heterodimer cleaves pro-MST1 to form MST1 dimer

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