Reactome | SARDH:FAD oxidatively demethylates SARC to Gly

Schema > Reaction > Entries

SARDH:FAD oxidatively demethylates SARC to Gly Show undefined attributes

catalystActivity	[CatalystActivity:10300307] sarcosine dehydrogenase activity of SARDH:FAD [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10300309
displayName	SARDH:FAD oxidatively demethylates SARC to Gly
eventOf	[Pathway:R-CFA-6798163] Choline catabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Canis familiaris
inferredFrom	[Reaction:R-HSA-6797913] SARDH:FAD oxidatively demethylates SARC to Gly - Homo sapiens
input	[SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-6797917] SARC [mitochondrial matrix] [SimpleEntity:R-ALL-9979086] THFpolyGlu [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SARDH:FAD oxidatively demethylates SARC to Gly (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + oxidized (electron-transfer flavoprotein) + H(+) => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced (electron-transfer flavoprotein) + glycine
output	[SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix] [SimpleEntity:R-ALL-159549] Gly [mitochondrial matrix] [SimpleEntity:R-ALL-9979072] MeTHFpolyGlu [mitochondrial matrix]
precedingEvent	[Reaction:R-CFA-6797653] DMGDH:FAD oxidatively demethylates DMGLY to SARC - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6797913
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CFA-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
(hasEvent)	[Pathway:R-CFA-6798163] Choline catabolism
(inferredTo)	[Reaction:R-HSA-6797913] SARDH:FAD oxidatively demethylates SARC to Gly

Cite Us!