Reactome | CCNK binds CDK12

Schema > Reaction > Entries

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10300117
displayName	CCNK binds CDK12
eventOf	[Pathway:R-CFA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Canis familiaris
inferredFrom	[Reaction:R-HSA-6797090] CCNK binds CDK12 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-6796619] CCNK [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-6797012] CDK12 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CCNK binds CDK12
output	[Complex:R-CFA-6797095] CCNK:CDK12 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6797090
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-6796648] TP53 Regulates Transcription of DNA Repair Genes
(precedingEvent)	[Reaction:R-CFA-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes
(inferredTo)	[Reaction:R-HSA-6797090] CCNK binds CDK12