Reactome | IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3

Schema > Reaction > Entries

IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10298545
displayName	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
eventOf	[Pathway:R-CFA-6783783] Interleukin-10 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-6784006] STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 - Canis familiaris
inferredFrom	[Reaction:R-HSA-6784323] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 - Homo sapiens
input	[Complex:R-CFA-6784755] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] [EntityWithAccessionedSequence:R-CFA-539044] STAT3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
output	[Complex:R-CFA-6784795] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-CFA-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6784323
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6783783] Interleukin-10 signaling
(precedingEvent)	[Reaction:R-CFA-6784006] STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
(inferredTo)	[Reaction:R-HSA-6784323] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3

Cite Us!