Reactome | USP28 deubiquitinates CLSPN and MYC

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USP28 deubiquitinates CLSPN and MYC Show undefined attributes

catalystActivity	[CatalystActivity:10297964] cysteine-type deubiquitinase activity of USP28:PolyUb-CLSPN, PolyUb-MYC [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10297966
displayName	USP28 deubiquitinates CLSPN and MYC
eventOf	[Pathway:R-CFA-5689880] Ub-specific processing proteases - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5696914] USP28 deubiquitinates CLSPN and MYC - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-CFA-6783159] USP28:PolyUb-CLSPN, PolyUb-MYC [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	USP28 deubiquitinates CLSPN and MYC
output	[DefinedSet:R-CFA-6782682] PolyUb [nucleoplasm] [Complex:R-CFA-6783086] USP28:CLSPN,MYC [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5696914
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5689880] Ub-specific processing proteases
(inferredTo)	[Reaction:R-HSA-5696914] USP28 deubiquitinates CLSPN and MYC

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