Reactome | 5'- incision of DNA by ERCC1:ERCC4 in GG-NER

Schema > Reaction > Entries

5'- incision of DNA by ERCC1:ERCC4 in GG-NER Show undefined attributes

catalystActivity	[CatalystActivity:10296135] endonuclease activity of GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10296137
displayName	5'- incision of DNA by ERCC1:ERCC4 in GG-NER
eventOf	[Pathway:R-CFA-5696400] Dual Incision in GG-NER - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5690213] DNA polymerases delta, epsilon or kappa bind the GG-NER site - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:17134] nucleotide-excision repair
inferredFrom	[Reaction:R-HSA-5690990] 5'- incision of DNA by ERCC1:ERCC4 in GG-NER - Homo sapiens
input	[Complex:R-CFA-5691046] GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	5'- incision of DNA by ERCC1:ERCC4 in GG-NER
output	[Complex:R-CFA-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm]
precedingEvent	[Reaction:R-CFA-5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5690990
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5696400] Dual Incision in GG-NER
(precedingEvent)	[Reaction:R-CFA-5690213] DNA polymerases delta, epsilon or kappa bind the GG-NER site
(inferredTo)	[Reaction:R-HSA-5690990] 5'- incision of DNA by ERCC1:ERCC4 in GG-NER

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