Reactome | POLQ extends annealed 3'-ssDNA overhangs in MMEJ

Schema > Reaction > Entries

POLQ extends annealed 3'-ssDNA overhangs in MMEJ Show undefined attributes

catalystActivity	[CatalystActivity:10294860] DNA-directed DNA polymerase activity of Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10294862
displayName	POLQ extends annealed 3'-ssDNA overhangs in MMEJ
eventOf	[Pathway:R-CFA-5685939] HDR through MMEJ (alt-NHEJ) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ - Homo sapiens
input	[Complex:R-CFA-5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] [SimpleEntity:R-ALL-30555] dNTP [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	POLQ extends annealed 3'-ssDNA overhangs in MMEJ
output	[Complex:R-CFA-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
regulatedBy	[NegativeRegulation:10294863] Negative regulation by 'RAD52 heptamer [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5687640
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5685939] HDR through MMEJ (alt-NHEJ)
(inferredTo)	[Reaction:R-HSA-5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ

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