Reactome | MRN and RBBP8 resect DNA DSBs in MMEJ

Schema > Reaction > Entries

MRN and RBBP8 resect DNA DSBs in MMEJ Show undefined attributes

catalystActivity	[CatalystActivity:10294839] DNA endonuclease activity of DNA DSB:MRN:RBBP8 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10294841
displayName	MRN and RBBP8 resect DNA DSBs in MMEJ
eventOf	[Pathway:R-CFA-5685939] HDR through MMEJ (alt-NHEJ) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5687464] MRN and RBBP8 resect DNA DSBs in MMEJ - Homo sapiens
input	[Complex:R-CFA-5687468] DNA DSB:MRN:RBBP8 [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MRN and RBBP8 resect DNA DSBs in MMEJ
output	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-CFA-5687460] Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm]
precedingEvent	[Reaction:R-CFA-5687465] MRN complex binds RBBP8 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5687464
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5685939] HDR through MMEJ (alt-NHEJ)
(inferredTo)	[Reaction:R-HSA-5687464] MRN and RBBP8 resect DNA DSBs in MMEJ

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