Reactome | ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer

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ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer Show undefined attributes

catalystActivity	[CatalystActivity:10293695] protein-cysteine S-palmitoyltransferase activity of ZDHHC8 [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10293697
displayName	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer
eventOf	[Pathway:R-CFA-8963896] HDL assembly - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5682103] 4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane - Canis familiaris
inferredFrom	[Reaction:R-HSA-5682084] ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer - Homo sapiens
input	[Complex:R-CFA-5682087] ABCA1 tetramer [endoplasmic reticulum membrane] 12 × [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer
output	[Complex:R-CFA-5682067] 4xPALM-C-ABCA1 tetramer [endoplasmic reticulum membrane] 16 × [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5682084
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8963896] HDL assembly
(precedingEvent)	[Reaction:R-CFA-5682103] 4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane
(inferredTo)	[Reaction:R-HSA-5682084] ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer

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