Reactome | Regulation of RAS by GAPs

Schema > Pathway > Entries

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331271
displayName	Regulation of RAS by GAPs
eventOf	[Pathway:R-CFA-5673001] RAF/MAP kinase cascade - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-5658435] RAS GAPs bind RAS:GTP - Canis familiaris [Reaction:R-CFA-5658231] RAS GAPs stimulate RAS GTPase activity - Canis familiaris [Reaction:R-CFA-5658438] SPRED dimer binds NF1 - Canis familiaris [BlackBoxEvent:R-CFA-5658430] NF1 is degraded by the proteasome - Canis familiaris
inferredFrom	[Pathway:R-HSA-5658442] Regulation of RAS by GAPs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of RAS by GAPs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-5658442
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-5658442] Regulation of RAS by GAPs