Reactome | AKR1B1 reduces Glc to D-sorbitol

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AKR1B1 reduces Glc to D-sorbitol Show undefined attributes

catalystActivity	[CatalystActivity:10243014] aldose reductase (NADPH) activity of AKR1B1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10291235
displayName	AKR1B1 reduces Glc to D-sorbitol
eventOf	[Pathway:R-CFA-5652227] Fructose biosynthesis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5652195] SORD oxidizes D-sorbitol to Fru - Canis familiaris
inferredFrom	[Reaction:R-HSA-5652172] AKR1B1 reduces Glc to D-sorbitol - Homo sapiens
input	[SimpleEntity:R-ALL-70113] Glc [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AKR1B1 reduces Glc to D-sorbitol glucose + NADPH + H+ => sorbitol + NADP+
output	[SimpleEntity:R-ALL-5652213] D-sorbitol [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5652172
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5652227] Fructose biosynthesis
(precedingEvent)	[Reaction:R-CFA-5652195] SORD oxidizes D-sorbitol to Fru
(inferredTo)	[Reaction:R-HSA-5652172] AKR1B1 reduces Glc to D-sorbitol

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