Reactome | PTCH is internalized

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10290708
displayName	PTCH is internalized
eventOf	[Pathway:R-CFA-5632684] Hedgehog 'on' state - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5632677] PTCH is internalized - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-5632517] PTCH1 [ciliary membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PTCH is internalized
output	[EntityWithAccessionedSequence:R-CFA-5632520] PTCH1 [endocytic vesicle membrane]
precedingEvent	[Reaction:R-CFA-5635865] SMURF1/2 dissociates from ub-PTCH1 - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-5632677
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-5632684] Hedgehog 'on' state
(inferredTo)	[BlackBoxEvent:R-HSA-5632677] PTCH is internalized

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