Reactome | RHO GTPases activate PAKs

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RHO GTPases activate PAKs Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330409
displayName	RHO GTPases activate PAKs
eventOf	[Pathway:R-CFA-195258] RHO GTPase Effectors - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-2029456] RAC1 and CDC42 activate PAK1 - Canis familiaris [Reaction:R-CFA-8981931] RAC1 and CDC42 activate PAK2 - Canis familiaris [Reaction:R-CFA-8981926] RAC1 and CDC42 activate PAK3 - Canis familiaris [Reaction:R-CFA-5627775] Autophosphorylation of PAK1,2,3 - Canis familiaris [Reaction:R-CFA-2029460] PAK1 phosphorylates LIMK1 - Canis familiaris [Reaction:R-CFA-445797] MYLK (MLCK) Active Calmodulin Binding - Canis familiaris [Reaction:R-CFA-5668984] PAK1 or PAK2 phosphorylates MYLK - Canis familiaris [Reaction:R-CFA-5669158] NF2 binds PAK1 - Canis familiaris [Reaction:R-CFA-5669240] FLNA binds PAK1 - Canis familiaris [Reaction:R-CFA-5669250] PAK1 phosphorylates FLNA - Canis familiaris
inferredFrom	[Pathway:R-HSA-5627123] RHO GTPases activate PAKs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RHO GTPases activate PAKs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-5627123
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-CFA-5687128] MAPK6/MAPK4 signaling [Pathway:R-CFA-376176] Signaling by ROBO receptors [Pathway:R-CFA-8848021] Signaling by PTK6 [Pathway:R-CFA-5627117] RHO GTPases Activate ROCKs
(inferredTo)	[Pathway:R-HSA-5627123] RHO GTPases activate PAKs

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