Reactome | K63polyUb-TRAF6 ubiquitinates TAK1

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K63polyUb-TRAF6 ubiquitinates TAK1 Show undefined attributes

catalystActivity	[CatalystActivity:10289048] ubiquitin-protein transferase activity of p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10289050
displayName	K63polyUb-TRAF6 ubiquitinates TAK1
eventOf	[Pathway:R-CFA-5607764] CLEC7A (Dectin-1) signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5607732] K63polyUb-TAK1 autophosphorylates - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-5607757] K63polyUb-TRAF6 ubiquitinates TAK1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Polymer:R-CFA-450152] K63polyUb [cytosol] [Complex:R-CFA-5607672] p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] [Complex:R-CFA-202463] UBE2N:UBE2V1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	K63polyUb-TRAF6 ubiquitinates TAK1
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [Complex:R-CFA-5607695] p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] [SimpleEntity:R-ALL-111294] PPi [cytosol] [Complex:R-CFA-202463] UBE2N:UBE2V1 [cytosol]
precedingEvent	[Reaction:R-CFA-5607759] TRIKA2 binds K63polyUb-TRAF6 oligomer - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-5607757
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5607764] CLEC7A (Dectin-1) signaling
(precedingEvent)	[Reaction:R-CFA-5607732] K63polyUb-TAK1 autophosphorylates
(inferredTo)	[BlackBoxEvent:R-HSA-5607757] K63polyUb-TRAF6 ubiquitinates TAK1