Reactome | CHUK, IKBKB phosphorylate CYLD at S418

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CHUK, IKBKB phosphorylate CYLD at S418 Show undefined attributes

catalystActivity	[CatalystActivity:10238293] protein serine/threonine kinase activity of IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10287720
displayName	CHUK, IKBKB phosphorylate CYLD at S418
eventOf	[Pathway:R-CFA-5357905] Regulation of TNFR1 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5357831] CHUK, IKBKB phosphorylate CYLD at S418 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-CFA-741420] CYLD [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CHUK, IKBKB phosphorylate CYLD at S418 CYLD is phosphorylated by IKK
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-CFA-5212667] phospho-CYLD [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5357831
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5357905] Regulation of TNFR1 signaling
(inferredTo)	[Reaction:R-HSA-5357831] CHUK, IKBKB phosphorylate CYLD at S418

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