Reactome | TNFR1-induced proapoptotic signaling

Schema > Pathway > Entries

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328971
displayName	TNFR1-induced proapoptotic signaling
eventOf	[Pathway:R-CFA-75893] TNF signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:528734] death-inducing signaling complex assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Canis familiaris
inferredFrom	[Pathway:R-HSA-5357786] TNFR1-induced proapoptotic signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TNFR1-induced proapoptotic signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-5357786
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-75893] TNF signaling
(inferredTo)	[Pathway:R-HSA-5357786] TNFR1-induced proapoptotic signaling

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