Reactome | TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)

Schema > Reaction > Entries

TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10287707
displayName	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
eventOf	[Pathway:R-CFA-5357956] TNFR1-induced NF-kappa-B signaling pathway - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Canis familiaris
inferredFrom	[Reaction:R-HSA-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) - Homo sapiens
input	[CandidateSet:R-CFA-5357900] BIRC2,3,4 [cytosol] [Complex:R-CFA-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
output	[Complex:R-CFA-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
precedingEvent	[Reaction:R-CFA-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5357780
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5357956] TNFR1-induced NF-kappa-B signaling pathway
(precedingEvent)	[BlackBoxEvent:R-CFA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1
(inferredTo)	[Reaction:R-HSA-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)

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