Reactome | The Interleukin 1 receptor complex binds Tollip

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The Interleukin 1 receptor complex binds Tollip Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10257937
displayName	The Interleukin 1 receptor complex binds Tollip
eventOf	[Pathway:R-CFA-9020702] Interleukin-1 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-446868] The Interleukin 1 receptor complex binds Tollip - Homo sapiens
input	[Complex:R-CFA-446637] IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] [EntityWithAccessionedSequence:R-CFA-446885] TOLLIP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	The Interleukin 1 receptor complex binds Tollip
output	[Complex:R-CFA-446888] IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-446868
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9020702] Interleukin-1 signaling
(inferredTo)	[Reaction:R-HSA-446868] The Interleukin 1 receptor complex binds Tollip

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