Reactome | IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-CFA-446689] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] - Canis familiaris
consumedByEvent	[BlackBoxEvent:R-CFA-446684] IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation - Canis familiaris [Reaction:R-CFA-446692] IRAK1 binds to MYD88 within the IL1R complex - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10257895
displayName	IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane]
hasComponent	[Complex:R-CFA-445758] IL1R1:IL1:IL1RAP [plasma membrane] [Complex:R-CFA-193932] MYD88 dimer [cytosol] [EntityWithAccessionedSequence:R-CFA-446649] phospho-IRAK4 [cytosol] [EntityWithAccessionedSequence:R-CFA-446885] TOLLIP [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] - Homo sapiens
maxDepth	5
name	IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP
producedByEvent	[Reaction:R-CFA-446634] IRAK4 is activated by autophosphorylation - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-446643
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasComponent)	[Complex:R-CFA-446689] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] [Complex:R-CFA-446693] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] [Complex:R-CFA-446696] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane]
(output)	[Reaction:R-CFA-446634] IRAK4 is activated by autophosphorylation
(input)	[BlackBoxEvent:R-CFA-446684] IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation [Reaction:R-CFA-446692] IRAK1 binds to MYD88 within the IL1R complex
(inferredTo)	[Complex:R-HSA-446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane]