Reactome | Thyrotropin-releasing hormone receptor binds thyrotropin

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Thyrotropin-releasing hormone receptor binds thyrotropin Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10257367
displayName	Thyrotropin-releasing hormone receptor binds thyrotropin
eventOf	[Pathway:R-CFA-375276] Peptide ligand-binding receptors - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Canis familiaris
inferredFrom	[Reaction:R-HSA-444498] Thyrotropin-releasing hormone receptor binds thyrotropin - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-444548] TRH [extracellular region] [EntityWithAccessionedSequence:R-CFA-444556] TRHR [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Thyrotropin-releasing hormone receptor binds thyrotropin
output	[Complex:R-CFA-444479] TRH:TRHR [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-444498
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-375276] Peptide ligand-binding receptors
(precedingEvent)	[Reaction:R-CFA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
(inferredTo)	[Reaction:R-HSA-444498] Thyrotropin-releasing hormone receptor binds thyrotropin

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