Reactome | SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region

Schema > Reaction > Entries

SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region Show undefined attributes

catalystActivity	[CatalystActivity:10257124] ferrous iron transmembrane transporter activity of SLC40A1:HEPH:6Cu2+ [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10257126
displayName	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region
eventOf	[Pathway:R-CFA-917937] Iron uptake and transport - Canis familiaris [Pathway:R-CFA-425410] Metal ion SLC transporters - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Canis familiaris
inferredFrom	[Reaction:R-HSA-442368] SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-71067] Fe2+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region Ferroportin mediates iron influx across the basolateral membrane of enterocytes
output	[SimpleEntity:R-ALL-435347] Fe2+ [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-442368
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-425410] Metal ion SLC transporters [Pathway:R-CFA-917937] Iron uptake and transport
(precedingEvent)	[Reaction:R-CFA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+
(inferredTo)	[Reaction:R-HSA-442368] SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region

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