Reactome | Intracellular metabolism of fatty acids regulates insulin secretion

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Intracellular metabolism of fatty acids regulates insulin secretion Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330367
displayName	Intracellular metabolism of fatty acids regulates insulin secretion
eventOf	[Pathway:R-CFA-400451] Free fatty acids regulate insulin secretion - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:534] fatty acid metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-434381] CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol - Canis familiaris [Reaction:R-CFA-434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A - Canis familiaris
inferredFrom	[Pathway:R-HSA-434313] Intracellular metabolism of fatty acids regulates insulin secretion - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Intracellular metabolism of fatty acids regulates insulin secretion
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-434313
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-400451] Free fatty acids regulate insulin secretion
(inferredTo)	[Pathway:R-HSA-434313] Intracellular metabolism of fatty acids regulates insulin secretion

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