Reactome | Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding

Schema > Reaction > Entries

Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding Show undefined attributes

catalystActivity	[CatalystActivity:10256593] protein serine/threonine kinase activity of AKT1/PDK1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10256595
displayName	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
eventOf	[Pathway:R-CFA-354192] Integrin signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-432096] Activated integrin alphaIIb beta3 binds SHC1 - Canis familiaris
inferredFrom	[Reaction:R-HSA-432110] Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding - Homo sapiens
input	[Complex:R-CFA-114514] Integrin alphaIIb:beta3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
output	[Complex:R-CFA-432105] Integrin alpha IIb p(T779)-beta 3 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-432110
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-354192] Integrin signaling
(precedingEvent)	[Reaction:R-CFA-432096] Activated integrin alphaIIb beta3 binds SHC1
(inferredTo)	[Reaction:R-HSA-432110] Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding

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