Reactome | Sodium/Calcium exchangers

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Sodium/Calcium exchangers Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330297
displayName	Sodium/Calcium exchangers
eventOf	[Pathway:R-CFA-425410] Metal ion SLC transporters - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:422838] calcium ion transmembrane transport
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-425661] SLC8A1,2,3 exchange 3Na+ for Ca2+ - Canis familiaris [Reaction:R-CFA-425678] SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ - Canis familiaris [Reaction:R-CFA-5626316] SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Canis familiaris [Reaction:R-CFA-425822] K+-independent Li+/Ca2+ exchanger transport - Canis familiaris
inferredFrom	[Pathway:R-HSA-425561] Sodium/Calcium exchangers - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Sodium/Calcium exchangers
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-425561
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-425410] Metal ion SLC transporters
(inferredTo)	[Pathway:R-HSA-425561] Sodium/Calcium exchangers

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