Reactome | Active Rac1 interacts with Plexin-B1:Sema4D

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Active Rac1 interacts with Plexin-B1:Sema4D Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10254081
displayName	Active Rac1 interacts with Plexin-B1:Sema4D
eventOf	[Pathway:R-CFA-416550] Sema4D mediated inhibition of cell attachment and migration - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-400677] Rnd1 interacts with Plexin-B1:Sema4D - Canis familiaris
inferredFrom	[Reaction:R-HSA-400682] Active Rac1 interacts with Plexin-B1:Sema4D - Homo sapiens
input	[Complex:R-CFA-442641] RAC1:GTP [plasma membrane] [Complex:R-CFA-419621] SEMA4D:MET:p-Y-PLXNB1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Active Rac1 interacts with Plexin-B1:Sema4D Active Rac1 interacts with Plexin-B1:Sema4A
output	[Complex:R-CFA-400679] Sema4D:pPlexin-B1:Met:RAC1-GTP [plasma membrane]
precedingEvent	[Reaction:R-CFA-419646] SEMA4D interacts with Plexin-B1:Met - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-400682
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-416550] Sema4D mediated inhibition of cell attachment and migration
(precedingEvent)	[Reaction:R-CFA-400677] Rnd1 interacts with Plexin-B1:Sema4D
(inferredTo)	[Reaction:R-HSA-400682] Active Rac1 interacts with Plexin-B1:Sema4D

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