Reactome | p190RhoGEF exchanges GTP for GDP on RHOA, activating it

Schema > Reaction > Entries

p190RhoGEF exchanges GTP for GDP on RHOA, activating it Show undefined attributes

catalystActivity	[CatalystActivity:10158749] guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10158751
displayName	p190RhoGEF exchanges GTP for GDP on RHOA, activating it
eventOf	[Pathway:R-CFA-3928662] EPHB-mediated forward signaling - Canis familiaris
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-3928576] RHOA:GTP binds ROCK, activating it - Canis familiaris
inferredFrom	[Reaction:R-HSA-3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-CFA-8964174] RHOA:GDP [plasma membrane]
isInDisease	false
isInferred	true
name	p190RhoGEF exchanges GTP for GDP on RHOA, activating it
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-CFA-5665993] RHOA:GTP [plasma membrane]
precedingEvent	[Reaction:R-CFA-3928598] Recruitment of p190RhoGEF to p-FAK - Canis familiaris
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-3928592
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-3928662] EPHB-mediated forward signaling
(precedingEvent)	[Reaction:R-CFA-3928576] RHOA:GTP binds ROCK, activating it
(inferredTo)	[Reaction:R-HSA-3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it

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