Reactome | NCAM signaling for neurite out-growth

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NCAM signaling for neurite out-growth Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329801
displayName	NCAM signaling for neurite out-growth
eventOf	[Pathway:R-CFA-422475] Axon guidance - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-392051] Recruitment of Grb2 to pFAK:NCAM1 - Canis familiaris [Reaction:R-CFA-392053] SOS binds Grb2 bound to pFAK:NCAM1 - Canis familiaris [Reaction:R-CFA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Canis familiaris [Reaction:R-CFA-198756] ERK1/2 phosphorylates MSK1 - Canis familiaris [Reaction:R-CFA-199935] MSK1 activates CREB - Canis familiaris [Pathway:R-CFA-419037] NCAM1 interactions - Canis familiaris
inferredFrom	[Pathway:R-HSA-375165] NCAM signaling for neurite out-growth - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	NCAM signaling for neurite out-growth
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-375165
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-422475] Axon guidance
(hasEncapsulatedEvent)	[Pathway:R-CFA-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-375165] NCAM signaling for neurite out-growth

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